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Bioimpedance, a non-invasive method that measures the body s electrical resistance, can yield estimates of TBW and hence FFM and FM Regional fat distribution is best measured by magnetic resonance imaging (MRI) or computerized tomographic (CT) scanning Both are expensive and the latter incurs Food intake can be assessed from various questionnaires and food diaries Under-reporting of food intake, a consistent finding among obese people, can compromise these methods Total energy expenditure (TEE) comprises basal metabolic rate (BMR), thermogenesis (eg heat generated by food, fever or drugs) and physical activity BMR typically accounts for two-thirds of TEE and is proportional to FFM TEE rises with increasing body weight because FFM also rises, and is therefore higher in obese than in lean subjects.

Energy expenditure can be calculated from indirect calorimetry (using a portable ventilated hood apparatus, or a whole-body chamber suitable for studies lasting several days), or the isotopic doubly-labelled water method, which yields the carbon dioxide production rate over several days Physical activity can be measured by movement-sensitive accelerometers or from heart rate Insulin sensitivity and -cell function can both be estimated from fasting blood levels of insulin and glucose using homeostatic model assessment (HOMA) The intravenous glucose tolerance test (IVGTT) derives insulin sensitivity from the rate of disappearance of glucose following an intravenous bolus injection The euglycaemic hyperinsulinaemic clamp (EHC) determines insulin sensitivity from the amount of glucose that has to be administered intravenously to maintain a normal blood glucose level during intravenous infusion of insulin to stimulate glucose uptake into skeletal muscle..

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r The main sequence and three-dimensional structure archives available via the www. r How to access and download information from these archives. r How to analyse this information to extract functionally relevant data. r For primary structures, you will be able to align sequences, predict secondary structure, hydropathy

Drag-and-drop is easy to use. It s a helpful tool if you aren t sure where the file that you want is located because it s easier to navigate with Windows Explorer than from the Select Drawing File dialog box. You can also drag an object from one drawing to another. First open both drawings. It helps to be able to see them both at once. Choose Window Tile Vertically to see them side-byside. Select the object or objects that you want to copy. Now click the object or objects again, and hold down the mouse button until the cursor displays a small rectangle. Then drag the object(s) to the other drawing.

As part of developing the original 802.11b wireless networking standard, the need for a way to protect and secure wireless networks was already well understood. The solution developed to address the problem was called Wired Equivalent Privacy (WEP). As its name suggests, the idea behind this security scheme was to implement protective measures that would make a wireless network just as a secure as the wired alternatives. WEP functions by individually encrypting each and every packet sent between devices across a wireless network. It does this using a 64- or 128-bit encryption key stored on all WEP-enabled wireless devices. In some cases, the access point generates the key value, but it can also be configured manually. Ultimately, each device on the WEP-enabled wireless network must have the same encryption key value configured to securely encrypt and decrypt packets sent and received. Unfortunately, the technique used to secure WEP encryption keys has proven to be flawed. With the correct tools (and enough time), hackers can use a number of popular utilities to capture wireless traffic protected by WEP, crack its encryption key (the same key is used to encrypt all traffic), and ultimately gain access to these secured wireless networks.

9.2. THE MULTISITE SCHEDULING PROBLEM Scheduling problems are usually treated in a single plant environment where a set of orders for products has to be scheduled on a set of machines (Dorn and Froeschl, 1993; Sauer and Bruns, 1997; Zweben and Fox, 1994). However, within many industrial enterprises the production processes are distributed over several manufacturing sites, which are responsible for the production of various parts of a set of nal products. Usually, there is no immediate feedback from the local plants to the logistics department, and communication between the local schedulers takes place without any computer-based support. Figure 9.1 illustrates a hierarchical two-level structure of multisite scheduling re ecting the organizational structure often found in business. On the global

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